First Fix

de Mamiel

First Fix

Regular price $216.00
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Since its inception the de Mamiel brand has been built around EPiC - the three pillars of stress: emotional, physical and cellular. So, it came as no surprise to us that Annee de Mamiel would be among the first in world to create a serum that treats both the causes and symptoms of stress on our skin.

First Fix is the result of 13 years of dedicated research and development. Recently, science has taught us that our skin cells cannot only perceive stress on their own, but that they can also directly produce cortisol. Cortisol production from the skin cell can compromise barrier function, leave the skin looking dull, feeling dehydrated and irritated, and showing unwanted signs of premature aging. 

Containing a host of effective and reparative plant actives and extracts, this powerful serum will soothe, protect and repair skin back to health. In addition to finding some of the best ingredients found worldwide, de Mamiel has created the de Mamiel Cortisol Resilience Complex™ to address the emotional impact of stress. This aromatherapeutic blend triggers a change in the way we respond to stress.

  • 89% of testers said their skin felt more HYDRATED
  • 80% of testers said their skin appeared more RADIANT
  • 88% of testers said their skin felt SMOOTHER 

Suitable for all skin types, including those with sensitive skin.



NEUROPHROLINE™ Helps to counteract the negative effects of cortisol to visibly improve skin tone.

ECTION Supports a vulnerable barrier function and increases much-needed hydration.

ROUND-HEADED BUSH CLOVER Injects skin with vitality and helps decrease the tell-tale signs of fatigue.

PASSIOLINE™ An active that addresses a deteriorating skin structure. It is clinically proven to support elastin and collagen synthesis for a firmer texture.

TELOSENSE™ Protects and enhances skin DNA health.

SEABUCKTHORN ADAPTOGEN Boosts density and restores definition to skin that feels weakened.

RHODIOLA ROSEA Promotes skin energy.

BLUEBERRY POLYPHENOL Soothes and brightens tone to reinstate skin’s innate glow.

DE MAMIEL CORTISOL RESILIENCE COMPLEX™ Addresses the emotional impact of stress. An aromatherapeutic blend which includes Rose, Cape Chamomile, Vetiver and Sandalwood oils, and which triggers a change in the way we respond to stress.


Aqua/Water/Eau, Glycerin, Propanediol, Camellia Japonica (tsubaki) seed oil, Kappaphycus alvarezii (red algae) extract, Caryodendron orinocense (kahai) nut oil, Ectoin, Opuntia ficus indica (prickly pear) seed oil, Squalane, Helianthus annuus (sunflower) seed oil, Diheptyl succinate, Capryloyl Glycerin/Sebacic Acid Copolymer, Passiflora edulis (maracuja) seed oil, Punica granatum (pomegranate) seed oil, Cetearyl alcohol, Cetyl phosphate, L-Arginine, Benzyl alcohol, Curcuma longa (turmeric) Callus Lysate, Lespedeza capitata (roundhead bush clover) leaf/stem extract, Sodium hyaluronate, Maltodextrin, Salicylic acid, Lysolecithin, Sclerotium Gum, Tocopherol (Vitamin e), Vaccinium angustifolium (blueberry) Fruit Extract, Xanthan Gum, Parfum (Fragrance)**, Tephrosia purpurea (wild indigo) seed extract, Rhodiola Rosea (rhodiola) root extract, Vetiveria zizanoides (vetiver) root oil*, Hippophae rhamnoides (seabuckthorn) kernel extract, Pelargonium graveolens (rose geranium) leaf oil*, Santalum album (sandalwood) wood oil, Pullulan, Simmondsia chinensis (jojoba) seed oil*, Sorbic acid, Eriocephalus punctulatus (cape chamomile) flower oil*, Citric acid, Rosmarinus Officinalis (Rosemary) Leaf Extract, Sodium Benzoate, Hydrolyzed Soy Protein, Hydrolyzed Yeast Protein, Linalool˚, Citronellol˚, Geraniol˚, Citral˚ 

˚Natural essential oil constituents   


Flower and gem essences of Black-eyed Susan, Bush Fuchsia, Crowea, Jacaranda, Little Flannel Flower, Grey Spider Flower, Obsidian.

Dermatologically tested / Dermatologically approved / Clinically tested / Suitable for all skin types including sensitive skin

Recommended Use

Use in the evening, after cleansing and toning your skin.

Place 2-4 pumps in your palm. Rub your hands together to warm and activate the serum. Breathe in the aroma deeply, then massage over your face.

If you wear an exfoliating product at night, one containing acids, apply First Fix over the exfoliant.


How much should I use?
Around 2-4 pumps each time you use it is plenty.

How should I apply it?
As with every de Mamiel product, the ritual of application is as important as the product; in independent psychometric testing and electroencephalography testing (EEG), First Fix was found to significantly impact the positive emotions of testers, who reported a 93% increase in feelings of pleasure after using it. To use, take a moment's pause, apply a few pumps to fingertips and gently rub together to warm the product. Inhale deeply for a count of 3, pause, then exhale for a count of 5. Apply to skin working up and outwards from the jaw line.

When should I use it?
As with every skincare product, it's important to take time to listen to your skin. Although First Fix is primarily designed to be used in your evening routine, if your skin is in need of intensive repair or some extra TLC, then add it in as an extra step in your morning routine.

Where in my routine should I use it?
Use First Fix wherever you would use a serum. If you mix together multiple serums, apply First Fix after your serum mixture and before your moisturizer or oil. 

How long will the bottle last for?
Dependent on the usage, on average one bottle should last for approximately 70 days.

How long should I use it for?
First Fix can be used long-term as a preventative and reparative treatment.

How long will it take to see results?
This is dependent on the individual but based on our independent clinical trials, you should see results or changes in two weeks.