Senolytic Serum

Senolytic Serum is a targeted skin-longevity treatment developed to address cellular senescence, a hallmark of aging. Senescent cells are aging or stressed cells that have stopped dividing but remain active, releasing signals that can contribute to inflammation and visible signs of aging.

At the center of the formula is fisetin, a naturally occurring flavonoid extensively investigated in longevity research for its potential senolytic activity. To help preserve its integrity within an aqueous topical system, fisetin is delivered in an encapsulated form designed to protect it from degradation and support its stability.

Encapsulated fisetin is combined with astragalus root and Magnesium Ascorbyl Phosphate (MAP), a stable vitamin C derivative, to provide antioxidant support and help maintain healthy fibroblast function, promote collagen synthesis, and extracellular matrix integrity.

By supporting a healthier cellular environment, Senolytic Serum helps improve skin resilience and recovery capacity while complementing retinoids, antioxidants, peptides, and other age-delay treatments. Over time, skin appears smoother, firmer, more even-toned, and better able to respond to environmental and age-related stress.

FISETIN (COTINUS COGGYGRIA BRANCHES/LEAVES (SMOKE TREE)) A SENOLYTIC A naturally occurring flavonoid found in fruits and vegetables, fisetin acts as a senolytic compound, helping to support cellular longevity by reducing the accumulation of aged, stressed cells. Fisetin helps protect against oxidative stress, support healthy cellular turnover, and maintain resilience.

ASTRAGALUS ROOT An adaptogenic botanical rich in astragalosides, flavonoids, and polysaccharides, Astragalus helps protect skin from oxidative stress while supporting healthy fibroblast function and collagen production. Research on Astragalus and its active compounds suggests it can help counter the cellular stress and inflammatory signaling associated with skin aging, making it a natural fit for a formula designed to restore optimal skin function.

MAGNESIUM ASCORBYL PHOSPHATE A stable, water-soluble form of vitamin C, MAP helps defend skin against oxidative stress while supporting collagen synthesis and a more even, resilient complexion. By helping protect skin from the molecular damage that accumulates with age, MAP supports the structural integrity and healthy function of the extracellular matrix.

ALL INGREDIENTS

Water/Aqua/Eau, Vinegar, Hydroxypropyl Starch Phosphate, Dipropylene Glycol, Glyceryl Caprylate, Tocopherol Polysarcosine, Magnesium Ascorbyl Phosphate, Maltodextrin, Fisetin, Xanthophylls, Chitosan, Sodium Palmitoyl Proline, Glycerin, Propanediol, Nymphaea Alba Flower Extract, Caprylhydroxamic Acid, Phosphatidylcholine, Astragalus Membranaceus Root Powder, Lecithin, Tocopherol, Citric Acid, Alcohol Denat.

Shake well. Smooth 1-2 pumps onto face/neck/chest. If irritation occurs, discontinue use and consult physician. Keep in a cool, dry place out of direct light. *Use within 6 months of opening.

The Senolytic Serum is designed for regular maintenance of aging skin and is best incorporated once the skin is in a stable, healthy state.

We do not recommend using the Senolytic Serum immediately following an invasive or intentionally wounding procedure, such as laser resurfacing, microneedling, or other treatments that temporarily compromise the skin barrier. During the wound-healing process, senescent cells can play important physiological roles in repair and tissue remodeling.

Allow the skin to fully heal and the barrier to recover before introducing the Senolytic Serum. Once the recovery period is complete, the serum can be used as part of a regular skin longevity routine to support healthy skin biology over time.

In short: repair first, then address accumulated senescent cells as part of ongoing maintenance.

Does Senolytic Serum replace other actives in my regimen, such as retinol or an emulsion?
No. Senolytic Serum is designed to complement, rather than replace, other Marie Veronique products. It can be used alongside retinoids, antioxidants, and emulsions, with no contraindications within a Marie Veronique regimen.

By supporting a healthier cellular environment, Senolytic Serum helps promote skin responsiveness and complements the role of other age-delay actives in your regimen. Like all of our formulas, it can be used daily or incorporated throughout the week according to what works best for your skin and routine.

Where does Senolytic Serum fit into my regimen?
When using a complete regimen, apply it after Tonic/Mist and before Oil. If layering multiple serums, apply Senolytic Serum first.

Recommended order of application:
Cleanse → Tonic/Mist → Serum(s) → Oil → Emulsion → Balm 

We do not recommend using Senolytic Serum immediately following an invasive or intentionally wounding procedure, such as laser resurfacing, microneedling, or other treatments that temporarily compromise the skin barrier. During the wound-healing process, senescent cells can play important physiological roles in repair and tissue remodeling.

Can Senolytic Serum be used morning and night? 
Yes, though we recommend prioritizing evening application, when skin naturally enters a period of repair and recovery.

During the day, focus on antioxidant support and UV protection with ingredients such as vitamins C and B3, followed by sunscreen. In the evening, Senolytic Serum supports healthy cellular function and skin recovery. It can also be layered with Senolytic Balm for a more comprehensive nighttime approach to skin longevity.